Towards a Patient-Based Drug Discovery
Enteroendocrine Drug Discovery for Treatment of Metabolic Diseases
The Enteroendocrine Discovery Performance Unit at GlaxoSmithKline is focused on discovering and developing medicines that mimic the efficacy of Roux-en-Y gastric bypass surgery to treat metabolic diseases. Our strategy emanates from the findings that there are significant metabolic benefits to obese and obese diabetic patients that undergo Roux-en-Y gastric bypass surgery. In general, these patients experience ~30% weight loss while >80% of obese diabetics who undergo this surgery have complete “remission” of diabetes.