The GPCR Retreat focuses on advances in our understanding of how cells communicate with each other and the environment via G protein-coupled receptors (GPCRs), the largest class of membrane proteins and one of the largest classes of targets for drugs currently on the market. The principal objective of the GPCR Retreat is to provide a venue for students, postdoctoral fellows, and principal investigators from academia and industry to discuss and debate existing and novel concepts in receptor biology. One of the core values of the meeting is to promote interactions among all participants, particularly between trainees and principal investigators. Each year, approximately 2/3 of the participants are trainees. Registration is capped at 200 participants to promote an intimate environment. Over the years, the meeting has grown into one of the most recognized events in the field. That reputation has led to broad participation from the Great Lakes region and beyond.