The theme of the 2012 Annual Meeting of the American Society for Reproductive Medicine is “Setting the Course in Reproductive Medicine,” a maritime reference as we plot and steer our way to future advances in the scientific and clinical knowledge of reproductive medicine and biology. Our Society’s 68th annual meeting will be held in the beautiful city of San Diego. The 2012 Annual Meeting Scientific Program is designed specifically to meet the educational needs of both scientists and practitioners specializing in the fields of male and female reproductive biology and clinical medicine. Educational objectives and learning events in the meeting are strategically planned to encompass both applied and investigational reproductive health in males and females. The many live, interactive learning activities are targeted to address educational needs within the varied fields of reproductive medicine and biology, including infertility, reproductive endocrinology, reproductive organ surgery, reproductive genetics, embryology, fertility preservation, and sexuality. We will also cast a wide net on reproductive corollaries with sessions devoted to contraception, menopause, pediatric and adolescent gynecology, mental health, ethics, and reproductive medical practice administration. This year’s program will focus on translational, bench-to-bedside advances and will introduce two new endowed Symposia and the concept of “Surgery Day”. The 2012 Annual Meeting location is the warm, sunny, friendly city of San Diego, easily accessible from most domestic and foreign airports. Educational sessions will allow for the rapid transmission of information from international experts in their fields through a variety of educational activities: plenary lectures, postgraduate courses, symposia, interactive sessions and debates. Attendees also will have the opportunity for informal interaction in the accompanying non-CME program of oral and poster abstract presentations and roundtable discussions that will inform participants about the results of the most meritorious and most recently completed basic science and clinical trials with relevance to biologists and clinicians specializing in reproductive medicine. Substantial time for questions and answers between participants and presenters is scheduled in order to ensure the greatest learning opportunities for introspection and interaction.