Conversion and processing of small molecules by cellular metabolic networks provides the cell with the necessary nutrients, biomass precursors and energy resources. Metabolism has therefore traditionally been seen as a downstream effector layer in the regulatory architecture of the cell. Recent work, however, revealed that metabolism commands cellular and organismal physiology and is closely intertwined with multiple signalling pathways.
Studies on the mechanisms of metabolic sensing, characterisation of the system-level impact of metabolism on regulatory networks and discovery of new metabolic coordination mechanisms have provided unforeseen insights into the crosstalk between metabolism and cellular homeostasis, which show a remarkable evolutionary conservation.
This very active field of investigation is interdisciplinary in nature and requires a variety of approaches, from investigations at the molecular and cellular levels to system-wide genetic and integrative approaches in multiple species. This symposium will therefore bring together leading researchers from a variety of disciplines and disease areas to stimulate cross-fertilising discussions and exchanges.
The purpose of this symposium is to offer an integrated view of metabolism and highlight the emerging concept that metabolism exerts an important homeostatic role on multiple pathways involved in human disease, including tumour cell growth, inflammation, neuronal functions and epigenetic reprogramming.
Topic 1 - Mitochondria and metabolism
Topic 2 - Large-scale analysis of metabolism across species
Topic 3 - Metabolic sensors and effectors
Topic 4 - Stress pathways and metabolic homeostasis
Topic 5 - Stem cells, cancer and metabolism
Topic 6 - Metabolism and aging
Registration deadline 9 October 2014
Abstract submission deadline 28 August 2014
Artists / Speakers: Michael Hall, Gary Ruvkun, Johan Auwerx, Stefanie Dimmeler, Thomas Lemberger, Vamsi K. Mootha, Anne Brunet, Andy Dillin, Ronald Evans, Matthias Hentze, Nils-Göran Larsson, Leslie Leinwand, Jennifer Lippincott-Schwartz, Aldons J. Lusis, Matthias Lutolf, David Mangelsdorf, Eric Olson, Linda Partridge, Pier Giuseppe Pelicci, David Ron, Uwe Sauer, Kristina Schoonjans, Reuben Shaw, Anu Suomalainen, Thomas Langer, Albertha J Walhout, Rudolf Zechner