Python is a high-level programming language with a growing community in academia and industry. It is a general-purpose language adopted by many scientific applications such as computational fluid dynamics, bio molecular simulation, artificial intelligence, statistics and data analysis, scientific visualization etc. More and more industrial domains are turning towards it as well, such as robotics, semiconductor manufacturing, automotive solutions, telecommunication, computer graphics, and games. In all fields, the use of Python for scientific, high performance parallel, and distributed computing, as well as general scripted automation is increasing. Moreover, Python is well-suited for education in scientific computing. The workshop will bring together researchers and practitioners from industry and academia using Python for all aspects of high performance and scientific computing. The goal is to present Python applications from mathematics, science, and engineering, to discuss general topics regarding the use of Python (such as language design and performance issues), and to share experience using Python in scientific computing education.